The effect of Familact probiotic supplementation on lipid profile, glycemic control and insulin levels in patients with type 2 diabetes

Razmpoosh, Elham and Javadi, maryam (2015) The effect of Familact probiotic supplementation on lipid profile, glycemic control and insulin levels in patients with type 2 diabetes. Masters thesis, Qazvin university of Medical Sciences.

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Background: Probiotics are considered as functional food and has beneficial effects on human gastrointestinal health. They help the body improve the balance or homeostasis of these microorganisms. In some animal studies, the effects of probiotics in decreasing plasma glucose and delaying the onset of hyperglycemia and insulin resistance have been reported, though limited human studies are available. Objectives: Considering the ever-increasing prevalence of type 2 diabetes, the aim of the present study was to investigate the effects of probiotic supplement consisting of multi species of bacteria, on fasting plasma glucose, lipid profile and insulin resistance in type 2 diabetic patients. Methods: This randomized double blind clinical trial was carried out on 60 diabetic patients referred to Taleghani Hospital in Tehran. They were randomly divided into 2 groups of probiotics that received a daily dose of 1010 CFU of bacteria, and placebo groups that received a daily dose of 1000 mg magnesium stearat for 6 weeks (2 capsules per day in each group). Anthropometric measurements, fasting blood sugar, insulin, lipid profiles, insulin resistance and dietary intakes were measured at baseline and at the end of the study. Dietary intakes were measured by 24 hour and 3-day questionnaires and were analyzed by Nutritionist 4 software. Chi Square, Paired Samples t-test and Analysis of variance were performed by SPSS software for statistical analyses. Results: Mean fasting blood sugar was significantly decreased within probiotic group after intervention (P<0.001), while it was not significant between group comparisons. Moreover, mean HDL cholesterol levels were significantly increased in probiotic group (P<0.006), while this increase was not statistical significant between group comparisons (P>0.05). On the other hand, although a little increase was observed in total cholesterol and insulin levels an also a decreased level was seen in LDL cholesterol, weight, BMI, chest and waist circumferences, these changes were not statically significant neither in between group nor in within group comparisons (P>0.05). Conclusions: Considering the positive effect of probiotic supplements on reducing fasting plasma glucose and increasing the HDL cholesterol levels in type 2 diabetic patients, consumption of probiotics is recommended as Medication assistances in these patients in order to reduce the side effects of diabetes mellitus such as cardiovascular or hyperlipidemic diseases. Though, as limited human trials are available, more researches are needed to confirm these findings.

Item Type: Thesis (Masters)
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
Divisions: University Thesis > Faculty of Health > Health Science in Nutrition
Depositing User: Health School Students
Date Deposited: 25 Feb 2015 08:52
Last Modified: 07 Dec 2016 12:05
URI: http://eprints.qums.ac.ir/id/eprint/107

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