sofiabadi, mohammad and Zarbaf, Reyhaneh and Abdolahpour, A and Koushki Jahromi, M and Peymani, Amir and Khosravi, N (2020) Effect of exercise training before mating on mRNA expression of breast cancer-related genes in offspring in rats | [Effet de l'entraînement physique avant l'accouplement sur l'expression de l'ARNm de gènes liés au cancer du sein chez la progéniture du rat]. Science and Sports.
![[img]](http://eprints.qums.ac.ir/style/images/fileicons/application_pdf.png) |
PDF
Download (225kB) |
Abstract
Purpose. — Exercise is associated with reduced risk of breast cancer, however, effect of parental exercise on risk of breast cancer in children has not been studied. Thus, the aim of the present study was evaluating the effect of aerobic training of parents before pregnancy on the expression of some of the main genes in breast cancer in breast tissue of their offspring. Method. — Eighteen female and 6 male Sprague Dawley rats were randomly divided into two exercise training and control group. After training each male mated with 2 females. Parental aerobic training with moderate intensity was performed running on treadmill for 4 weeks, 5 sessions per week. Finally Pairs 4, 5, and 6 of adult breast tissues was performed to evaluate the expression of BRCA1, TP53, ER-, IGF-1 and IGF-1R.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | University Portal > research center > mmrc |
| Depositing User: | mmrc research portal |
| Date Deposited: | 21 Dec 2021 08:22 |
| Last Modified: | 21 Dec 2021 08:22 |
| URI: | http://eprints.qums.ac.ir/id/eprint/11149 |
Actions (login required)
 |
View Item |
