A Review of Immunomodulatory Effects of Fluoroquinolones

Assar, Shokrollah and Nosratabadi, Reza and Khorramdel Azad, Hossein and Masoumi, Javad and Mohamadi, Mahshad and Hassanshahi, Gholamhossein (2021) A Review of Immunomodulatory Effects of Fluoroquinolones. Immunological Investigations.

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Past researches indicate that some types of antibiotics, apart from their antimicrobial effects, have some other important effects which indirectly are exerted by modulating and regulating the immune system’s mediators. Among the compounds with antimicrobial effects, fluoroquinolones (FQs) are known as synthetic antibiotics, which exhibit the property of decomposing of DNA and prevent bacterial growth by inactivating the enzymes involved in DNA twisting, including topoisomerase II (DNA gyrase) and IV. Interestingly, immune responses are indirectly modulated by FQs through suppressing pro-inflammatory cytokines, such as interleukin 1 (IL-1), IL-6, tumor necrosis factor-alpha (TNF-α), and super-inducing IL-2, which tend to increase both the growth and activity of T and B lymphocytes. In addition, they affect the development of immune responses by influencing of expression of other cytokines and mediators. This study aims to review past research on the immunomodulatory effects of FQs on the expression of cytokines, especially IL-2 and to discuss controversial investigations.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: University Portal > research center > mmrc
Depositing User: mmrc research portal
Date Deposited: 22 Dec 2021 05:32
Last Modified: 22 Dec 2021 05:32
URI: http://eprints.qums.ac.ir/id/eprint/11188

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