The Effects of Prenatal Norharman Exposure on Seizure Severity in Rats

Esmaeili, Mohammad Hossein and Sofiabadi, Mohammad and Afshar, Amin (2021) The Effects of Prenatal Norharman Exposure on Seizure Severity in Rats. Journal of Inflammatory Diseases, 25 (1). pp. 19-24. ISSN 27174158

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Abstract

Background: Norhraman is an alkaloid that can damage the nervous system. Objective: This experimental study aimed to investigate the effects of prenatal norharman exposure on seizure severity in adult rats. Methods: A total of 36 Wistar rats were randomly divided into 3 groups as follows: Control, sham (solvent), and norharman (1000 ug/kg). The sham and norharman groups were treated once daily for 8-18 of the fetal period. 2 months after birth, kindling was performed by the daily injection of Pentylenetetrazol (PTZ) (30 mg/kg); then, the seizure behavior was recorded for approximately 30 minutes. The obtained data were analyzed using Analysis of Variance (ANOVA) and Tukey’s posthoc test. Results: The present study data indicated that administrating norharman in the fetal period increased seizure responses to PTZ, i.e., significant in the examined female rats (P<0.05). Conclusion: According to the current research findings, the severity of seizures increases in subjects who have been exposed to norharman during the prenatal period.

Item Type:	Article
Subjects:	Q Science > QP Physiology
Divisions:	University Portal > vice chancellor > vcr
Depositing User:	pr vcen research
Date Deposited:	22 Dec 2021 07:27
Last Modified:	22 Dec 2021 07:27
URI:	http://eprints.qums.ac.ir/id/eprint/11213

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