Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study

Javadi, Hamid Reza and Mirakbari, Seyed Mostafa and Allami, Abbas and Yazdi, Zohreh and katebi, kimia (2021) Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study. Indian Journal of Critical Care Medicine.

[img] PDF
Download (83kB)


Background: Toxicity and side effects of long-term use of opioids are well studied, but little information exists regarding electrophysiological disturbances of opium consumption. While natural opium has been regarded safe to a great extent among traditional communities, concerns are emerging owing to the available evidence of QT prolongation that have been exposed during recent outcome surveillance of patients under opioid use. Potential QT prolonging interactions would raise a higher level of such concern in opium users during COVID pandemic and warrant attention. Materials and methods: This study was designed to detect the prevalence of QTc prolongation among opium users and nonusers. Two groups were compared with regard to gender, age, and median QTc interval. Normal and prolonged QTc intervals of user group were compared with respect to age, sex, dose of opium consumption, and duration of opium consumption. Results: 123 opium users and 39 controls were investigated. Median QTc interval in opium user and non-user group was 460 vs 386 milliseconds, respectively (p value < 0.001). In all, 59.3%, (95% CI: 50.51–67.62%) of cases and none of non-user had prolonged QTc interval (p value < 0.001). There was no significance between normal and prolonged QTc intervals with respect to dose and duration of opium use. Conclusion: This study indicated that opium consumption is associated with QTc prolongation. This prolongation does not relate to dose and duration of opium use. Further study is propounded to assess the clinical significance of these results and to determine risk rating of opium compared to other opioids in this regard. Keywords: Opioids, Opium, QT interval, QT prolongation. Indian Journal of Critical Care Medicine (2020): 10.5005/jp-journals-10071-23596

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: University Portal > research center > Metabolic
Depositing User: pr Metabolic diseases research
Date Deposited: 14 Nov 2022 10:14
Last Modified: 14 Nov 2022 10:14
URI: http://eprints.qums.ac.ir/id/eprint/12211

Actions (login required)

View Item View Item