Association of hypogonadism with the severity of chronic obstructive pulmonary disease

Zohal, mohammadali and Hashemipour, Sima and Karamali, Narges and Farzam, Seyyed Amir and Sami, Ramin (2015) Association of hypogonadism with the severity of chronic obstructive pulmonary disease. The Journal of Qazvin University of Medical Sciences. (Submitted)

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Abstract

Abstract Background: Advanced chronic obstructive pulmonary disease (COPD) is associated with weight loss and muscular weakness. Low serum testosterone may be contributed to muscle wasting. Objective: The present study is designed. to investigate the prevalence of hypogonadism and its correlation with the severity of COPD in Iranian patients with COPD. Methods: Fifty seven outpatients COPD patients in two groups of mild and sever class were selected. Level of total and free testosterone, FEV1, smoking, corticosteroid usage were determined. Frequency of hypogonadism was compared between two groups using chi square. Adjusted mean of testosterone was compared between two groups by ANCOVA. Findings: based on serum free testosterone level, 26.7% in mild group and 22.2% in sever group had hypogonadism. Mean of total and free testosterone were not significantly different between two groups (3.2±1.5ng/ml and 3.9±1.6pg/ml in mild group and 3.3±1.1ng/ml and 4.2±1.7pg/ml in sever group).After adjusting for age, body mass index, corticosteroid usage and smoking mean of total and free testosterone remained non-significantly different between two groups. Conclusion: Hypogonadism occurs frequently in COPD patients. In clinical stable patients, testosterone level does not associated with severity of disease.

Item Type:	Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	University Thesis > Faculty of Medicine > Internal medicine
Depositing User:	Medicine School Students
Date Deposited:	18 Apr 2015 03:54
Last Modified:	18 Apr 2015 03:54
URI:	http://eprints.qums.ac.ir/id/eprint/123

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