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Assessment of the effect of human growth hormone treatment on short stature children born with low birth weight

safari, fatemeh and hoda, hassani (2015) Assessment of the effect of human growth hormone treatment on short stature children born with low birth weight. hoda hassani.

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Abstract

Background: Almost 10% of all live neonates worldwide are born small for gestational age (SGA) due to multiple causes included maternal, placental and demographic factors. SGA is associated with an increased risk of short stature. We aimed to estimate the efficacy of growth hormone (GH) treatment in Iranian short stature children born small for gestational age (SGA). Methods: In a clinical trial study we evaluated the 6 months of GH treatment in 148 short children (106 girls, 42 boys) with SGA. Age, bone age, gestational age, gender, birth weight, tanner stage, term and preterm, GH level and height velocity were measured at baseline. GH hormone at a dose of 0.18-0.36 ng/ml/week was given to the subjects for 6 months. Height was estimated by follow up every month to document height velocity (cm/year). Subsequently, the difference between the height velocity before and after GH treatment was compared. Results: Of 148 SGA children with mean age of 8.7±2.8 years and birth weight of 2.3±0.3 Kg, more than two-thirds (70.3%) were children of preterm birth. With a mean bone age of 7.5±3.7 years, 52% of subjects were in tanner 1. At baseline, the average of GH level was 7.8±0.9 μg/L. Median height increased from 4.1±0.6 (cm/year) at the start to 8.7±0.9 (cm/year) at the end of 6 months GH treatment which was significantly different (p<0.001). No correlation between height velocity after GH treatment with age, bone age, gestational age, gender, birth weight, tanner stage, term and preterm birth was observed (p>0.05). Conclusion: Remarkable increase in height during first six months of GH treatment suggesting short children born SGA can be effectively be treated by hormone therapy. Keywords: Small for Gestational Age, Growth hormone, Treatment

Item Type: Book
Subjects: R Medicine > R Medicine (General)
Divisions: University Thesis > Faculty of Medicine > Pediatrician
Depositing User: Medicine School Students
Date Deposited: 29 Apr 2015 09:06
Last Modified: 29 Apr 2015 09:06
URI: http://eprints.qums.ac.ir/id/eprint/137

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