Rutin activates the MAPK pathway and BDNF gene expression onbeta-amyloid induced neurotoxicity in rats

Moghbelinejad, Sahar and Nassiri-Asl, Marjan and Naserpour Farivar, Taghi and Abbasi, Esmail and Sheikhi, Mehdi and Taghiloo, Mina and Farsad, Farzaneh and Samimi, Amir and Hajiali, farid (2014) Rutin activates the MAPK pathway and BDNF gene expression onbeta-amyloid induced neurotoxicity in rats. Toxicology Letters Journal.

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Flavonoids are present in foods such as fruits and vegetables. A relationship between the consumption offlavonoid-rich foods and prevention of human disease including neurodegenerative disorders has beendemonstrated. We assessed the effect of rutin (3,3�,4�,5,7-pentahydroxyflavone-3-rhamnoglucoside) onthe mitogen-activated protein kinase (MAPK) pathway, memory retrieval and oxidative stress in ratsinjected with �-amyloid (A�), which is implicated to have an important role in Alzheimer’s disease (AD).A� was injected bilaterally in the deep frontal cortex of rat brain. Next, rutin and saline were injected(i.p.) for 3 weeks. In comparison to the control group, rutin significantly increased extracellular signal-regulated protein kinase 1 (ERK1), cAMP response element-binding protein (CREB) and brain-derivedneurotrophic factor (BDNF) gene expression in the hippocampus of rats. Rutin (100 mg/kg) significantlyincreased memory retrieval compared to the control group. Malondialdehyde (MDA) level in the hip-pocampus of the rutin group was significantly lower than those in the control group. The content ofsulfhydryl groups in the rutin group was higher than that in the control group. The findings show apossibility that rutin may have beneficial effects against neurotoxicity of A� on memory in rats.

Item Type: Article
Subjects: R Medicine > RH Basic Medical Sciences > RH1001 Biochemistry & Genetics
Divisions: University Portal > research center > camr
Depositing User: pr Camr research
Date Deposited: 16 Sep 2015 05:27
Last Modified: 16 Sep 2015 05:27
URI: http://eprints.qums.ac.ir/id/eprint/2596

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