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The Effect of Fenugreek (Trigonella foenum-graecum) Seed and 17-β Estradiol on Serum Apelin, Glucose, Lipids, and Insulin in Ovariectomized Rats

Abedinzade, Mahmood and Nasri, Sima and Jamal Omidi, Masome and Porramezan, Bizhan and Khanaki, Korosh (2015) The Effect of Fenugreek (Trigonella foenum-graecum) Seed and 17-β Estradiol on Serum Apelin, Glucose, Lipids, and Insulin in Ovariectomized Rats. Biotechnology and Health Sciences.

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Abstract

Background: Menopause, a natural phenomenon, is defined by the fall of ovarian hormones mainly estrogens causing major problems such as insulin resistance. Fenugreek (Trigonella foenum-graecum) is known to have some useful properties such as insulin sensitizing effect. Apelin is an adipokine, which has several roles such as regulation of insulin secretion. Objectives: The objective of the present study was to evaluate the effect of fenugreek seed and 17-β estradiol on serum Apelin along with glucose, lipids and insulin in ovariectomized rats. Materials and Methods: Forty-nine adult female Wistar rats were randomly divided to seven groups: normal control, ovariectomized control, ovariectomized treated with ethanolic and hexanic extract of fenugreek seed (50 and 150 mg/kg/daily for each), and ovariectomized treated with 17-β estradiol (10 μg/kg/daily) for 42 days. Serum Apelin, glucose, lipids and insulin were measured. Results: Serum Apelin, glucose, lipids and insulin significantly increased in ovariectomized controls in comparison with normal controls (P < 0.05). Serum glucose, lipids and insulin in ovariectomized rats treated with fenugreek seed extract and 17-β estradiol were remarkably lower than ovariectomized controls (P < 0.05). Furthermore, 17-β estradiol caused a significant decrease (P < 0.05) in serum Apelin in ovariectomized rats. Conclusions: It appears that fenugreek seed might be effective against hyperglycemia, hyperlipidemia and insulin resistance in ovariectomized rats without impact on serum Apelin. Furthermore, 17-β estradiol could have similar effects along with possible inhibitory effects on serum Apelin. The complicated role of Apelin in menopause needs to be further explored. Keywords: Apelin-13; Trigonella Foenum-Graecum; 17 Beta-Estradiol; Ovariectomized; Insulin; Lipids

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: University Portal > vice chancellor > vcr
Depositing User: pr vcen research
Date Deposited: 03 Oct 2015 08:00
Last Modified: 03 Oct 2015 08:00
URI: http://eprints.qums.ac.ir/id/eprint/2729

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