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Compare the efficacy of Indomethacin and magnesium Sulphate in prevention of preterm labor

Abasalizadeh, Shamsi and Azar Fakhraei, Mehri and Ghojazadeh, Morteza and Abasalizadeh, Fatemeh and Raouf, Shiva and Haji Seid Javadi, Ezzatalsadat Compare the efficacy of Indomethacin and magnesium Sulphate in prevention of preterm labor. international journal of current reaserch and academic review.

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Abstract

Premature labor is responsible for almost 75% of all neonatal deaths and cause 50% of childhood neurological complications. Postponing the treatment of preterm labor and delivery, increased infant survival and better quality of life and is reduce costs of care for premature infants. The aim of this study was to compare the effect of Indomethacin and magnesium sulfate to prevent preterm labor. In a clinical trial study that performed in Department of Obstetrics & Gynecology of Tabriz University of Medical Sciences on patient with preterm labor, the effects of Indomethacin and magnesium sulfate to prevent preterm labor, evaluated. Mean time interval between beginning of pain to patient labor in Indomethacin group was 83.01 ± 91.53 hour and mean time interval between beginning of pain to patient labor in Magnesium Sulfate group was 83.76 ± 127.42 hour that significant difference was not found in mean time interval between beginning between both groups(P=0.968). In our study, Magnesium Sulphate in 32% and 60% of patients was caused to delayed delivery of more than 24 and 48 hours and Indomethacin in 37% and 63% of Patients was caused to delayed delivery of delayed delivery was more than 24 and 48 hours. Mean of first minute Apgar of case group (Indomethacin) was significantly more than mean of first minute Apgar in Control group and significant difference was not found in Mean of first minute Apgar between case and control groups. 41 of neonates in Case group and 47 of neonates in control group were alive. Our study, Indomethacin was effective in reducing preterm labor and as, Magnesium Sulphate has beneficial effects. Also, no significant differences was found in terms of fetuses born at birth between the two groups (P=0.294).

Item Type: Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: University Portal > research center > kcrdu
Depositing User: kosarunit Research portal
Date Deposited: 26 Nov 2015 07:17
Last Modified: 26 Nov 2015 07:17
URI: http://eprints.qums.ac.ir/id/eprint/3046

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