Effect of Probiotic in treatment of recurrent vulvovaginal candidiasis

Haji Seid Javadi, Ezzatalsadat and Taghizadeh, Sepehr and Haghdoost, Mehdi and Oweysee, Hamid Effect of Probiotic in treatment of recurrent vulvovaginal candidiasis. international journal of current reaserch and academic review.

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Recurrent vulvovaginal candidiasis infection is considered as the incidence of at least 3 or 4 independent vulvovaginal candidiasis infection with specific clinical symptoms and laboratory confirmation in a year that doesn't have to do with antibiotic therapy. Some of these studies have shown that probiotic lactobacilli are highly effective in the treatment of candidiasis vulvovaginal. The aim of this study was to evaluate the effect of probiotic therapy in patients with candidiasis vaginitis compared with the standard treatment. In a doubleblind randomized clinical trial which was performed on women with recurrent vaginitis candidiasis in Department of Obstetrics and Gynecology of Qazvin University of Medical Sciences and Department of infectious diseases of Tabriz University of medical sciences, recurrent vaginitis candidiasis infection status (resistant to treatment and relapse more than 3 times) and the responses to therapy in the patients were evaluated. There existed significant differences in the case and control groups before treatment in matters of symptoms. These symptoms included itching (P=0.359), vulvovaginal burning (P=0.414), disuria (P=0.494), dyspareunia (P=0.499), abnormal vaginal discharges (P=0.785), as well as deep pelvic pain (P=0.488). Patients in the case group were significantly lower than control group in the case of some symptoms after treatment such as frequency and the intensity of the itching (P=0.003), disuria (P=0.046), dyspareunia (P=0.006), abnormal vaginal discharges (P=0.015) and deep pelvic pain (P=0.031), while frequency of vulvovaginal burning after treatment had no important difference between two groups (P=0.061).At the end of the study, 3 patients from case group and 11 patients of control group had shown no responses to the treatment and their disease intensified. The intensifying rate and lack of response to treatment in patients of case group (under the supplemental treatment with the probiotic) were significantly lower than patients in control group (P = 0.019). The results of the present study showed that a combined treatment using probiotic materials in addition to the use of routine treatments is effective for patients with recurrent recurrent vulvovaginal candidiasis. This combines strategy leads to increased response of patients to treatment and dramatically reduction of frequency and severity of symptoms in patients, so as to the frequency and severity of these symptoms was lower in case compared to the control group after the treatment.

Item Type: Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: University Portal > research center > kcrdu
Depositing User: kosarunit Research portal
Date Deposited: 26 Nov 2015 07:39
Last Modified: 26 Nov 2015 07:39
URI: http://eprints.qums.ac.ir/id/eprint/3049

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