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Comparison of Topical Sucralfate and Silver Sulfadiazine Cream in Second Degree Burns in Rats

Beheshti, Akram and Shafigh, Younes and Abdollah Zangivand, Amir and Samiee-Rad, Fatemeh and Hassanzadeh, Gholamreza and Shafigh, Navid Comparison of Topical Sucralfate and Silver Sulfadiazine Cream in Second Degree Burns in Rats. Adv Clin Exp Med 2013, 22, 4, 481–487.

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Abstract

Background. The most prevalent topical treatment for partial thickness burns is silver sulfadiazine 1% (SSD). Recent studies have shown that the healing of partial thickness burns is delayed with the use of SSD. One of the potential burn dressings is sucralfate. Objectives. With this study the authors have aimed to analyze comparatively the effects of sucralfate and SSD on second degree burn wounds in rats. Material and Methods. Forty-eight male rats were divided into three equal groups. A burn model was constituted on the back of all rats. The burned areas in the first, second and third groups were covered daily with sucralfate, SSD and cold cream (control), respectively. At the end of the 7th, 14th, 21st and 28th day, the rats were anesthetized and the burned skin tissue samples were collected for histopathological examination. Results. At the end of the study, the epidermis and horny layer was completely formed in the SSD and sucralfate group; however the appendix of skin was just formed in the sucralfate group. Also the percentage of wound healing was calculated at 76%, 91% and 100% respectively in the control, silver sulfadiazine and sucralfate groups. Conclusions. Sucralfate is known to have multiple beneficial effects on wound healing. Using topical sucralfate accelerates the burn wound healing process in comparison with both the control and SSD groups and can be used as an adjunctive or alternative agent in the future (Adv Clin Exp Med 2013, 22, 4, 481–487).

Item Type: Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: University Portal > research center > kcrdu
Depositing User: kosarunit Research portal
Date Deposited: 04 Jan 2016 08:09
Last Modified: 04 Jan 2016 08:09
URI: http://eprints.qums.ac.ir/id/eprint/3459

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