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The effect of adding hyoscine to vaginal misoprostol on shortening the time of abortion induction

Haji Seid Javadi, Ezzatalsadat and Ghaffari, Samira and Movahed, Farideh and Javadi, Amir and Mashrabi, Omid The effect of adding hyoscine to vaginal misoprostol on shortening the time of abortion induction. African Journal of Pharmacy and Pharmacology Vol. 7(2), pp. 46-49, 15 January, 2013.

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Abstract

Induced abortion is the termination of pregnancy by medical or surgical methods before the fetus’ viability. Available evidences show that due to spasmolytic effects, use of Hyoscine with Misoprostol may reduce the pain during abortion induction. The aim of this study is to evaluate the effect of Misoprostol in combination with Hyoscine compared with Misoprostol alone in reducing the duration of abortion induction. In a clinical trial at the Department of Obstetrics and Gynecology, Qazvin University of Medical Sciences on 126 pregnant women with gestational age below 20 weeks elected for abortion, the effect of Misoprostol in combination with Hyoscine compared with Misoprostol alone was evaluated in reducing the duration of abortion induction. The mean duration of abortion induction in Misoprostol with Hyoscine represented statistically significant decrease compared with Misoprostol (653.38 ± 80.386 min, with 726.29 ± 64.56 min) (P ≤ 0.001). There was no significant difference in demographic characteristics, including maternal age, gestational age, gravidity, parity and history of abortion between the two study groups, and the two groups were homogeneous. Duration of abortion induction (p < 0.001), the rate of vaginal bleeding (p < 0.001), and the rate of hemoglobin deficiency (p = 0.002) in the group receiving Misoprostol suppositories and Hyoscine was significantly lower than in the group receiving Misoprostol suppositories alone. The need for analgesics in the group receiving Misoprostol suppositories and Hyoscine was significantly less than in the group receiving Misoprostol suppositories alone (p < 0.001). Finally, results of this study showed that adding 20 mg Hyoscine intra venous to vaginal Misoprostol is effective in significantly reducing the duration of the abortion induction, getting less pain killers, less vaginal bleeding and less decrease in hemoglobin changes.

Item Type: Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: University Portal > research center > kcrdu
Depositing User: kosarunit Research portal
Date Deposited: 04 Jan 2016 08:53
Last Modified: 04 Jan 2016 08:53
URI: http://eprints.qums.ac.ir/id/eprint/3464

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