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Kinesin-1 Traffic Control in Neuronal Highway

Rahmati, Masoud (2016) Kinesin-1 Traffic Control in Neuronal Highway. Biotechnology and Health Sciences, 3 (2). ISSN 2383-028x

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Abstract

Context: The current study aimed to review research articles concerning kinesin-1 traffic control in the neuronal highways Evidence Acquisition: This review article compromised previous studies published since 1980 using PubMed, Google scholar, Embase, Medline, science direct and SID databases according to the keywords. Results: Kinesin-1 often recognizes scaffold proteins or adaptor proteins and binds to cargo membrane proteins directly as part of a protein complex. Several kinases and microtubule associated proteins are identified in the regulation of motor-cargo unloading. The mechanisms by which kinesin-1 recognizes and binds to specific cargos, and how to unload cargo and determine the direction of transport, are now identified. Conclusions: In summary, the current review article demonstrated that some proteins such as adaptors, Scaffolds, chaperons and microtubule associated proteins and some metabolites, hormones, protein kinases and exercise training can regulate kinesin-1 traffic control in neuronal highway. These findings open exciting new areas of kinesin-1 research. Keywords: Kinesin-1, Scaffold Proteins, Adaptor Proteins, Neuronal Transport

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: University Portal > vice chancellor > vcr
Depositing User: pr vcen research
Date Deposited: 07 Sep 2016 08:38
Last Modified: 08 Sep 2016 03:43
URI: http://eprints.qums.ac.ir/id/eprint/5132

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