Assessment of Vitamin K2 Levels in Osteoporotic Patients: A Case Control Study

Noori, Akram and Lashkari1, Mahin and Oveisi, Sonia and Khair Khah1, Mohamad Reza and Zargar1, Ali (2014) Assessment of Vitamin K2 Levels in Osteoporotic Patients: A Case Control Study. Global Journal of Health Science, 6 (6). pp. 82-87. ISSN 1916-9744

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Abstract

Objective: The aim of this study was to measure the level of Vitamin K2 (Vit K2) in osteoporotic patients and individuals with normal bone density as controls. Materials and Methods: This case-control study was done in Outpatient Department of Rheumatology at Qazvin Boo-ali Sina Hospital in 2013. Participants were 50 patients with osteoporotic densitometry measured by DEXA (T score≤ -2.5) who were matched with 48 persons in control group with normal bone density (T score> -1). The level of Vit K2 in samples was measured using enzyme linked immunosorbent assay (ELISA). Data were analyzed by Mann-Whitney U test and Chi-square test. Results: The level of Vit K2 in patients with osteoporosis was not significantly different from the control group (Median: 75.95 vs. 71.35 nmol/L, respectively; P-value: 0.709). The authors determined cut-offs 75 percentile of vitamin K2 in all participants that was 85 nmol/L and percentages of persons in two groups were similar. Conclusion: Although Vit K2 level in patients with osteoporosis was not significantly different from the control group, further studies are necessary to confirm the association of osteoporosis and Vit K2. Keywords: bone densitometry, normal bone density, osteoporosis, vitamin K2

Item Type:	Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	University Portal > research center > Metabolic
Depositing User:	pr Metabolic diseases research
Date Deposited:	09 Jun 2015 04:22
Last Modified:	09 Jun 2015 04:22
URI:	http://eprints.qums.ac.ir/id/eprint/529

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