Comparison of the therapeutic effect of melatonin, metformin and vitamin E in patients with non-alcoholic fatty liver disease under a diet program

Khajeh Jahromi, Sina (2017) Comparison of the therapeutic effect of melatonin, metformin and vitamin E in patients with non-alcoholic fatty liver disease under a diet program. Masters thesis, Qazvin University of Medical Sciences, Qazvin, Iran.

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Abstract

Introduction and objectives: Understanding the best treatment for non-alcoholic fatty liver (NAFLD) as its prevalence growing is necessary. In this study we evaluated and compared the therapeutic effects of three drugs metformin, vitamin E and melatonin in patients with NAFLD. Materials and methods: This double blinded randomized clinical trial conducted on 3 groups contain 30 patients with NAFLD. For all patients we administrated same diet regimen and changing the life style by increasing the activity time of the day. Drugs administrated randomly and patients followed for 3 months. Metformin 500 mg per day, Vitamin E 400 IU per day and melatonin 3mg per day was administered. At the beginning and the end of the study, the weight of patients,BMI, liver aminotransferases, lipid factors and fasting blood glucose were evaluated. Data were analyzed by SPSS software version 20. Results: Metformin, vitamin E and melatonin all of them were able to significantly reduce the level of aminotransferases (P <0.05). In compare of the groups, ALT, AST, cholesterol and LDL levels were significantly different between the two groups of metformin and melatonin (P <0.05). It was also observed that weight lost can independently improve disease condition. Conclusion: Melatonin can improve the hepatic injury factors and lipid metabolism and also fasting the repairing process. Metformin also do so but especially more powerful in improving the lipid factors. Vitamin E can reduce the hepatic injury factors remarkably.

Item Type:	Thesis (Masters)
Subjects:	R Medicine > RC Internal medicine
Divisions:	University Thesis > Faculty of Medicine
Depositing User:	Medicine School Students
Date Deposited:	05 Oct 2017 04:33
Last Modified:	05 Oct 2017 04:33
URI:	http://eprints.qums.ac.ir/id/eprint/6859

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