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Detection of human CMV PP65 protein in glioma brain tumors with immunohistochemistry method

Jabbari, Mohammadreza and Sabahi, Farzaneh and Khansarinejad, Behzad and Shirkoohi, Reza and Saberi, Hoshang and Parvin, Mahmoud (2015) Detection of human CMV PP65 protein in glioma brain tumors with immunohistochemistry method. The Journal of Qazvin University of Medical Sciences, 19 (3). pp. 4-10. ISSN 24235814

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Abstract

Background: Human cytomegalovirus (HCMV) may play a role in the development of glioma disease that is one of the most common brain tumors. Objective: The aim of this study was to detect human CMV in patients with glioma in Imam Khomeini hospital, Tehran. Methods: This experimental study was conducted on paraffin-embedded tumor samples of 18 patients referred to Imam Khomeini hospital in 2012. Immunohistochemistry (IHC) was performed with monoclonal antibody specific for HCMV PP65 protein and the samples were assessed using a light microscope. Findings: Of 18 patients, 13 (72.2%) were positive for HCMV PP65 protein and four of them expired. Conclusion: With regards to the results, more comprehensive studies are recommended for detection of HCMV in patients with glioma using different diagnostic methods. Keywords: Cytomegalovirus, Immunohistochemistry, Glioma

Item Type: Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: University Portal > vice chancellor > vcr
Depositing User: pr vcen research
Date Deposited: 22 Jan 2018 09:41
Last Modified: 22 Jan 2018 09:41
URI: http://eprints.qums.ac.ir/id/eprint/7185

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