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The effects of Frankincense on lipid peroxidation and plasma antioxidant levels in patients with rheumatoid arthritis "A Randomized Clinical Trial"

khadem haghighian, hosein and noroozi, soheila (2017) The effects of Frankincense on lipid peroxidation and plasma antioxidant levels in patients with rheumatoid arthritis "A Randomized Clinical Trial". Masters thesis, qazvin university of medical sciences,qazvin,iran.

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Abstract

Background and Aim: Rheumatoid arthritis is an autoimmune disease that inflammatory mediators play an important role in pathogenesis. Although the pathology of rheumatoid arthritis is unknown, the imbalance between pro-inflammatory and anti-inflammatory cytokines is important in creating it. Studies have suggested the role of various types of Interleukins and α-Tumor Necrosis Factor in inflammation and ultimately pathogenicity of the disease. The levels of lipid peroxidation and malondialdehyde levels in the serum of patients with this disease increase. Based on the antioxidant and anti-inflammatory properties of frankincense, this study was conducted to determine the effect of oral frankincense on lipid peroxidation and antioxidant levels of plasma in patients with rheumatoid arthritis. Materials and Methods: Sixty patients with rheumatoid arthritis were randomly divided into two groups of 30 subjects. For 90 days, the first group daily received 3 capsules of 500 mg of frankincense and the second group daily received 3 capsules of 500 mg of white flour. Before entering the study, all patients were clinically examined. The blood test included lipid profiles, rheumatoid factor and malondialdehyde, and C reactive protein before and after intervention in the same laboratory after 12 hours of fasting. And finally the data using the software spss 16 were analyzed using Paired Samples Test. Results: At the end of the study, there was a significant decrease in lipid peroxidation index (P = 0.038) and serum total antioxidant capacity (P > 0.000) in the placebo group. The lipid peroxidation index (P = 0.036) and serum total antioxidant capacity (P = 0.002) showed a significant increase in the frankincense group. Among the studied variables, the level of LDL-C (P = 0.036) In the frankincense group showed a significant decrease compared to placebo group. Conclusion: In this study, serum levels of LDL in the group receiving frankincense showed a significant decrease if other variables showed no significant changes. Keywords: Rheumatoid Arthritis, Frankincense, Inflammatory Markers, Lipid Profile, Oxidative stress.

Item Type: Thesis (Masters)
Subjects: R Medicine > R Medicine (General)
Divisions: University Thesis > Faculty of Health > Health Science in Nutrition
Depositing User: Health School Students
Date Deposited: 12 Feb 2018 07:27
Last Modified: 12 Feb 2018 07:27
URI: http://eprints.qums.ac.ir/id/eprint/7241

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