A randomized controlled multimodal behavioral intervention trial for improving antiepileptic drug adherence

Pakpour, Amir H and Gholami, Maryam and Esmaeili, Ravanbakhsh and Naghibi, Seyed Abolhasan and John A, Updegraff and Molloy, Gerard J and Dombrowski, Stephan U (2015) A randomized controlled multimodal behavioral intervention trial for improving antiepileptic drug adherence. Epilepsy & Behavior.

[img] PDF
Download (367kB)


Purpose: Medication nonadherence is one of the most important reasons for treatment failure in patients with epilepsy. The present study investigated the effectiveness of a multicomponent intervention to improve adherence to antiepileptic drug (AED) medication in patients with epilepsy. Methods: In a prospective, randomizedmulticenter trial, three sessions of face-to-facemotivational interviewing (MI) in combination with complementary behavior change techniques were compared with standard care.Motivational interviewing prompted change talk and self-motivated statements from the patients, planning their own medication intake regimen and also identifying and overcoming barriers thatmay prevent adherence. Participants were provided with calendars to self-monitor their medication taking behavior. A family member and the health-care teamwere invited to attend the last session ofMI in order to improve the collaboration and communication between patients, their caregiver or family member, and their health-care provider. At baseline and 6-month follow-up, psychosocial variables and medical adherence were assessed. Results: In total, 275 participantswere included in the study. Comparedwith the active control group, patients in the intervention group reported significantly highermedication adherence, aswell as stronger intention and perceptions of control for taking medication regularly. The intervention group also reported higher levels of action planning, coping planning, self-monitoring, and lower medication concerns. Conclusions: This study shows that MI can be effective in clinical practice to improvemedication adherence in patientswith epilepsy. It also provides evidence that combining volitional interventions, including action planning, coping planning, and self-monitoring withmotivational interviewing can promote the effectiveness of the medical treatments for epilepsy by improving adherence

Item Type: Article
Subjects: R Medicine > RA Public aspects of medicine
Divisions: University Portal > research center > sdh
Depositing User: pr SDH research
Date Deposited: 09 Apr 2018 08:12
Last Modified: 09 Apr 2018 08:12
URI: http://eprints.qums.ac.ir/id/eprint/7310

Actions (login required)

View Item View Item