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Comparison of diagnostic accuracy of serologic test with histology for Helicobacter pylori in diabetic patients with dyspepsia

Salimi, Masoumeh and Sohrabi, Mohammad Bager and Zolfaghari, Poneh and Mirghasemi, Mehri and Yahyaei, Elahe and Sarrafha, Javad (2016) Comparison of diagnostic accuracy of serologic test with histology for Helicobacter pylori in diabetic patients with dyspepsia. The Journal of Qazvin University of Medical Sciences, 19 (6). pp. 14-20. ISSN 24235814

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Abstract

Background: Helicobacter pylori infection is a major cause of gastric diseases in humans that its rapid, simple and low cost diagnosis is important. Diabetes mellitus increases the risk of Helicobacter pylori infection. Objective: The aim of this study was to compare diagnostic accuracy of serologic test with histology for Helicobacter Pylori in diabetic patients with dyspepsia. Methods: This analytical study was conducted on 183 diabetic patients with dyspepsia referred to Imam Hossain hospital of Shahroud in 2014. All patients underwent endoscopy. Standard biopsy was performed as gold standard which included six gastric and duodenal samples. Simultaneously, blood samples were taken for serologic test. The presence of Helicobacter pylori was examined using Giemsa staining in histological study. Anti-Helicobacter pylori IgG was measured using ELISA in serological study. Sensitivity, specificity, and positive and negative predictive values were calculated. Data were analyzed using Chi-square test. Findings: Of 183, 104 patients (57.1%) were positive for Helicobacter pylori in serological study and 151 patients (82.5%) were positive in histological study. The sensitivity, specificity, positive predictive value and negative predictive value of serologic test for diagnosis of Helicobacter pylori were 64.2%, 78.1%, 93.3%, and 31.6%, respectively. IgG cut point for diagnosis of Helicobacter pylori was set to be 1.4 (sensitivity: 92.4% and specificity: 75.3%). Conclusion: The serologic test can be used as screening test for Helicobacter pylori in diabetic patients with regards to relatively high sensitivity and specificity as well as its simplicity, rapidity, and low price. Keywords: Helicobacter Pylori, Diabetes Mellitus, Serologic Tests, Histology, Sensitivity and Specificity

Item Type: Article
Subjects: Q Science > QR Microbiology
Divisions: University Portal > vice chancellor > vcr
Depositing User: pr vcen research
Date Deposited: 17 Mar 2018 05:30
Last Modified: 17 Mar 2018 05:30
URI: http://eprints.qums.ac.ir/id/eprint/7370

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