The effect of fish oil on two-step tuberculin test in hospitalized patients: A randomized controlled trial

Arfa, Narjes and Allami, Abbas (2018) The effect of fish oil on two-step tuberculin test in hospitalized patients: A randomized controlled trial. The Journal of Qazvin University of Medical Sciences, 21 (6). pp. 22-29. ISSN 24235814

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Background: According to national tuberculosis control guide, two-step tuberculin skin test (TST) should be done in the elderly, if the initial test is negative. However, it raises questions about the usefulness of this approach. Objective: This study aimed to explore the effects of fish oil supplements on the two-step tuberculin test in hospitalized patients. Methods: In this randomized controlled clinical trial, 128 patients randomly allocated to control group (receiving placebo, n=64) and treatment group (receiving fish oil supplements, n=64) during 2016. Fish oil supplement group was treated with 2 g daily for 4 consecutive days. The outcome was considered a change in 2 sequential TST induration sizes. Significant increase in the size of the secondary induration compared to primary was considered 6 mm or more. Findings: There was significant difference between primary and secondary indurations of two groups (higher in treatment group) (P=0.04). According to the results of analysis of variance and correlation tests, two effective factors were identified: initial induration and residence location (P=0.014 and P=0.002, respectively). In both groups, no clinically significant increase in the size of induration was observed. Conclusion: It seems that the number of cases considered as infected with tuberculosis does not increase with two- rather than one-step tuberculin skin test. Also, the short-term administration of fish oil supplements does not change this result. Keywords: Fish oils, Polyunsaturated fatty acids, Dietary supplements, Tuberculin test, Clinical trial

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: University Portal > vice chancellor > vcr
Depositing User: pr vcen research
Date Deposited: 19 Apr 2018 05:57
Last Modified: 19 Apr 2018 05:57
URI: http://eprints.qums.ac.ir/id/eprint/7445

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