alizadeh, fatemeh and Javadi, maryam and khadem haghighian, hosein and Karami, Ali Akbar (2018) Investigating the effect of curcumin supplementary on sperm parameters, inflammatory markers, oxidative stress markers and sex hormone levels in men with idiopathic infertility. Masters thesis, Qazvin university of Medical Sciences,Qazvin,Iran.
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Abstract
Background and aim: Approximately 20% of couples worldwide are infertile and about half of these couples having male infertility. In the meantime, impaired sperm production, decreased sperm motility, increased reactive oxygen species and increased level of plasma and seminal oxidative stress are the major causes of male infertility.The color of turmeric is because of a substance called curcumin for which some anti-oxidative and anti-inflammatory properties have been identified. This study aimed to investigating the effect of curcumine Supplementary on sperm parameters, inflammatory markers, oxidative stress markers, and sex hormone levels in men with idiopathic infertility. Material and methods: This study was a randomized double-blind controlled clinical trial, in which from among 70 men attending infertility subspecialty clinic of Velayat hospital in Qazvin in 1395, a total of 60 men with Asthenospermia, (with total sperm motility less than 50%, and rapid and progressive sperm move in the direct path less than 25%) were selected and assigned to one of two groups of intervention or placebo (n =30) groups using simple randomization (card shuffling). The intervention group took 80 mg curcumine nanomicell daily (2 capsules of 40 mg) for 12 weeks, and the placebo group took three placebo capsules daily. The parameters of sperm, total antioxidant capacity, malondialdehyde concentration, inflammatory markers and plasma sex hormones, anthropometric measurements, and physical activity at the beginning and the end of the study were determined. Statistical analysis was performed using SPSS software. Results: After the intervention the number, the concentration and the percentage of motile sperms, and also the total antioxidant capacity were significantly increased and the concentration of MDA and plasma inflammatory markers were significantly decreased in the intervention group (p<0.05). The changes in the sex hormones were significant neither in intervention group nor in the placebo group. Conclusion: According to the above mentioned results, in the infertile men with Asthenospermia who received curcumine, reduction in oxidative stress and inflammatory factors, and increase in sperm concentration and motility were observed, but there were no changes in sex hormones. Since an increase in reactive oxygen species in disorders of sperm was observed, receiving plants which have antioxidant capacity such as curcumine potentially can be one way to deal with sperm oxidative damages in this group of infertile men. Keywords: curcumine, Asthenozoospermia, Oxidative Stress, Inflammatory Markers
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RN Health > RN1005 Health Sciences in Nutrition |
| Divisions: | University Thesis > Faculty of Health > Health Science in Nutrition |
| Depositing User: | Health School Students |
| Date Deposited: | 14 May 2018 07:23 |
| Last Modified: | 14 May 2018 07:23 |
| URI: | http://eprints.qums.ac.ir/id/eprint/7500 |
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