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Investigating the effect of propolis supplementary on sperm parameters, inflammatory markers, oxidative stress markers and sex hormone levels in men with idiopathic infertility

gholaminejad, fereshteh and Javadi, maryam and khadem haghighian, hosein and karami, aliakbar (2018) Investigating the effect of propolis supplementary on sperm parameters, inflammatory markers, oxidative stress markers and sex hormone levels in men with idiopathic infertility. Masters thesis, Qazvin University of Medical Sciences,Qazvin,Iran.

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Abstract

Abstract Background and aim: Fertility has high value in most cultures. Sperm deficiency is one of the major factors that affecting male infertility. One of the effective factors in performance deficiency and reduced sperm motility is the increasing of reactive oxygen species, which leads to increase in oxidative levels. This study aimed to investigating the effect of propolis Supplementary on sperm parameters, inflammatory markers, oxidative stress markers and sex hormone levels in men with idiopathic infertility. Material and methods: This study was a randomized double-blind controlled clinical trial, in which from among 70 men attending infertility subspecialty clinic of Velayat hospital in Qazvin in 1395, a total of 60 men with Asthenospermia, (with total sperm motility less than 50%, and rapid and progressive sperm move in the direct path less than 25%) were selected and assigned to one of two groups of intervention or placebo (n =30) groups using simple randomization (card shuffling). The intervention group took 1500 mg propolis daily (three capsules of 500 mg) for 12 weeks, and the placebo group took three placebo capsules daily. The parameters of sperm, total antioxidant capacity, malondialdehyde concentration, inflammatory markers and plasma sex hormones, anthropometric measurements, and physical activity at the beginning and the end of the study were determined. Statistical analysis was performed using SPSS 16 software. Results: After the intervention the number, the concentration and the percentage of motile sperms (with degrees a, c, a+b, a+b+c), and also the total antioxidant capacity were significantly increased and the concentration of MDA and plasma inflammatory markers were significantly decreased in the intervention group (p<0.05). The changes in the sex hormones were significant neither in intervention group nor in the placebo group. Conclusion: According to the above mentioned results, in the infertile men with Asthenospermia who received propolis, reduction in oxidative stress and inflammatory factors, and increase in sperm concentration and motility were observed, but there were no changes in sex hormones. Considering the beneficial effects of the antioxidant activity of propolis and its ability to neutralize reactive oxygen species, it might be a good idea to treat infertility in infertile men. Key words: Infertility, Propolis,Asthenozoospermia, Oxidative Stress.

Item Type: Thesis (Masters)
Subjects: R Medicine > RN Health > RN1005 Health Sciences in Nutrition
Divisions: University Thesis > Faculty of Health > Health Science in Nutrition
Depositing User: Health School Students
Date Deposited: 14 May 2018 07:23
Last Modified: 14 May 2018 07:23
URI: http://eprints.qums.ac.ir/id/eprint/7501

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