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In vitro protoscolicidal effects of various concentrations of Ziziphora tenuior L. extract at different exposure times

Shahnazi, Mojtaba and Azadmehr, Abbas and Latifi, Robabeh and Hajiaghaee, Reza and Saraie, Mehrzad and Alipour, Mahmoud (2016) In vitro protoscolicidal effects of various concentrations of Ziziphora tenuior L. extract at different exposure times. Avicenna Journal of Phytomedicine.

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Abstract

Objective: Hydatidosis is one of the most important zoonotic diseases and surgery is still the main treatment for this problem. One of the side effects of hydatid cyst surgery is recurrence, thus, searching and assessment of some new agents such as medicinal plant extracts are very important. In the present study, the scolicidal effect of ethanolic extract of Ziziphora tenuior (Z. tenuior) was investigated. Materials and Methods: Protoscolices were aseptically collected from sheep livers containing hydatid cyst and used in the experiments. Z. tenuior extract was used at concentration of 3-100 mg/ml for 10-60 min. Viability of protoscolices was determined by 0.1% eosin staining. Results: Based on our results, Z. tenuior extract at concentration of 10 mg/ml killed all protoscolices after 20 min. However, this medicinal plant at concentration of 25 mg/ml destroyed all protoscolices in a shorter exposure time (10 min). Therefore, the scolicidal activity of the extract at 10 and 25 mg/ml concentrations was considerably effective in lower concentrations and shorter exposure times. Conclusion: The findings of this study showed that the ethanolic extract of Z. tenuior produces high scolicidal activity; it may be used as an appropriate and effective scolicidal agent in hydatidosis surgery. This is the first report on the protoscolicidal activity of Z. tenuior.

Item Type: Article
Subjects: R Medicine > RQ Parasitology
Divisions: University Portal > research center > camr
Depositing User: pr Camr research
Date Deposited: 30 May 2018 06:40
Last Modified: 30 May 2018 06:40
URI: http://eprints.qums.ac.ir/id/eprint/7623

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