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Prevention of Adhesion Bands by Ibuprofen-Loaded PLGA Nanofibers

Jamshidi-Adegani, Fatemeh and Seyed-Jafari, Ehsan and Gheibi, Dr. Nematollah and Soleimani, Masoud and sahmani, mehdi (2016) Prevention of Adhesion Bands by Ibuprofen-Loaded PLGA Nanofibers. Journal of American Institute of Chemical Engineers.

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Abstract

In this study, prevention of the adhesion bands and inflammatory features has been investigated using poly (lactic-co-glycolic acid)-ibuprofen (PLGA-IB) nanofibrous meshes in a mice model. To find the optimized membrane for prevention of postoperative adhesion bands, we have compared PLGA-IB group with PLGA, IB, and control groups in a mice adhesion model. Two scoring adhesion systems were used to represent the outcome. According to the results obtained in this study, the PLGA-IB nanofiber membrane showed a greater reduction in adhesion band than other groups. In conclusion, among FDA-approved polymers and drugs, PLGA-IB meshes could be applicable as a potential candidate for prevention of postoperative abdominal inflammation and adhesion bands formation. VC 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:990–997, 2016 Keywords: intraperitoneal adhesion, poly(lactic-co-glycolic acid), ibuprofen

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: University Portal > research center > camr
Depositing User: pr Camr research
Date Deposited: 30 May 2018 07:00
Last Modified: 30 May 2018 07:00
URI: http://eprints.qums.ac.ir/id/eprint/7628

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