Plasmid-mediated quinolones resistance in clinically important bacteria

Omidvar Panah, Maryam and Najafi, Maryam and Peymani, Amir (2018) Plasmid-mediated quinolones resistance in clinically important bacteria. The Journal of Qazvin University of Medical Sciences, 22 (2). pp. 90-99. ISSN 24235814

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Quinolones are synthetic and commonly used antibiotics for treatment of multiple clinical infections in the world. Quinolones are clinically important antibiotics, as an ideal component, because of high potency, broad-spectrum activity, good bioavailability and a potentially low incidence of side-effects. These antibiotics are not originated from biological source. In addition to chromosomal mutations in the target genes which confer resistance to these antibiotics, in recent years, plasmids-mediated quinolone resistance (PMQR) have made difficult to treat infections caused by resistant organisms. PMQR plays a very important role in resistance to these antibiotics due to the rapid spread between the bacteria. So far, three types of PMQR have been identified, including the aac(6')-Ib-cr, the qepA efflux pump and the qnr proteins. In this research, the role of qnr proteins in the development of drug resistance to the quinolone compounds has been studied. Keywords: Quinolone, Drug resistance, Qnr protein

Item Type: Article
Subjects: Q Science > QR Microbiology
Divisions: University Portal > vice chancellor > vcr
Depositing User: pr vcen research
Date Deposited: 23 Sep 2018 07:01
Last Modified: 02 Dec 2018 05:42
URI: http://eprints.qums.ac.ir/id/eprint/8102

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