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Effect of propolis supplementation on fructosamine, activity of antioxidant enzyme catalase and the oxidized-LDL level in patients with type 2 diabetes

Hesami, Sepideh and Khadem Haghighian, Hossein (2018) Effect of propolis supplementation on fructosamine, activity of antioxidant enzyme catalase and the oxidized-LDL level in patients with type 2 diabetes. Masters thesis, Qazvin University of Medical Science, Qazvin, Iran.

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Abstract

Abstract: Background and aim: Diabetes is one of the most common metabolic diseases. It is undeniable that oxidative-inflammatory condition is a major factor in its pathogeneses and complications. Previous studies claimed that diabetic chronic hyperglysemia aggrevates oxidative situations. This study aimed to evaluate antioxidant properties of propolis effect on fructosamine level, the catalase activity, and the level of oxidized-LDL in type 2 diabetic patients. Material and Methods: 60 type 2 diabetic patients, were randomly assigned to one of intervention and placebo groups (n =30). Participants in the intervention group took propolis capsule (500 mg) 3 times a day and those in the placebo group took placebo capsules for 8-week. Fructosamine level, catalase activity and the level of oxidized-LDL were measured in the base and end of the study. Statistical analysis was performed using SPSS v-20 software. Results: Findings showed fructosamine (P=0.02), and the level of oxidized-LDL (P=0.004) decreased noticeably, and catalase activity (P=0.03) improved significantly in propolis treated group. However, these changes in the placebo group were not significant. Conclusion: Propolis as a supplement in type 2 diabetes has a potential to improve anti-oxidant defense and decline production of hyperglycemia-induced byproducts such as fructosamine. Keywords: Propolis, Type 2 diabetes, Fructosamine, Catalase activity, Oxidized-LDL.

Item Type: Thesis (Masters)
Subjects: R Medicine > RN Health > RN1005 Health Sciences in Nutrition
Divisions: University Thesis > Faculty of Health > Health Science in Nutrition
Depositing User: Health School Students
Date Deposited: 22 Dec 2018 05:38
Last Modified: 22 Dec 2018 05:38
URI: http://eprints.qums.ac.ir/id/eprint/8380

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