soleimani, adel and Mirakbari, Seyed Mostafa (2019) Comparison of elevated troponin I with APACHE II score and SAPS II score in predicting mortality rate and major adverse outcomes in critically ill intoxicated patients. Masters thesis, qazvin university of medical sciences,qazvin,iran.
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Abstract
ABSTRACT Objective: Scoring the severity of the disease and predicting the mortality rate in each patient can be done with the clinical evaluation of the patient by a specialist physician so that a more accurate chance of survival can be assessed. Due to the limited research done especially in Iran regarding the scoring of severity of disease in patients with acute poisoning, this study aimed to compare of elevated troponin I with Acute Physiologic and Chronic Health Evaluation 2 (APACHE II) score and Simplified Acute Physiology Score 2 (SAPS II) score in predicting mortality rate and major adverse outcomes in critically ill intoxicated patients Materials and Methods: This descriptive-analytic cross-sectional study was performed on all patients who were referred to Booali hospital affiliated to Qazvin University of Medical Sciences in 2017 due to acute poisoning. In the first 24 hours, APACHE II and SAPS II scores and also level of troponin I were assessed and their relation with complications and death as well as the number of admission days were evaluated using SPSS 24 software. In addition, the diagnostic value of these three indicators to predict mortality due to poisoning was examined using the ROC curve. Results: 55 patients were enrolled in the study. The results of this study showed that the mean score of APACHE II and SAPS II and troponin I was significantly higher in patients who eventually died or had complications due to poisoning than uncomplicated patients. Based on the ROC curve, the SAPS II, APACHE II and troponin I sensitivity were 100%, 100% and 87%, respectively, and their specifity were 81%, 66% and 60%, respectively, and the cutoff points were 38, 13.5 and 0.009 ng/ml respectively. Conclusion: It seems that troponin I is not superior to SAPS II and APACHE II to predict the mortality in critically ill intoxicated patients. To achieve more reliable results, further studies on the predictive role of troponin I in intoxicated patients are recommended. Keywords: Troponin I, Acute Physiologic and Chronic Health Evaluation 2, Simplified Acute Physiology Score 2, Prediction, Mortality, Poisoning
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | University Thesis > Faculty of Medicine |
| Depositing User: | Medicine School Students |
| Date Deposited: | 30 Jul 2019 07:32 |
| Last Modified: | 30 Jul 2019 07:32 |
| URI: | http://eprints.qums.ac.ir/id/eprint/8860 |
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