Pakniat, Hamideh and Bahman, Atityeh and ansari, iman (2019) The Relationship of Pregnancy-Associated Plasma Protein A and Human Chorionic Gonadotropin with Adverse Pregnancy Outcomes: A Prospective Study. The Journal of Obstetrics and Gynecology of India, 69 (5). pp. 412-419. ISSN 0971-9202
![[img]](http://eprints.qums.ac.ir/style/images/fileicons/application_pdf.png) |
PDF
Download (501kB) |
Abstract
bstract Purpose: This prospective study investigated the relationship between pregnancy-associated plasma protein A (PAPP-A) and human chorionic gonadotropin (hCG) and adverse pregnancy outcomes in the Iranian population. Materials: Overall, 994 singleton pregnant mothers of 18-35-year old were referred for first-trimester screening tests, including PAPP-A and β-hCG, at the age of 6 days and 11-13 weeks, and were followed until the end of their pregnancy. The adverse pregnancy outcomes, PAPP-A, and β-hCG serum levels were recorded and analyzed. The sensitivity and specificity of the test were measured by calculating the area under the curve of receiver operating characteristic curve (ROC). Results: The mean serum level of PAPP-A and β-hCG was 1.10 ± 0.69 and 1.09 ± 0.8 MoM, respectively. Pregnancy-associated plasma protein A, regardless of its percentile, showed a significant relationship with the incidence of preeclampsia, preterm birth, and fetal low birth weight (p < 0.001 for each). However, the relationship between PAPP-A and abortion was not significant (p > 0.05). According to ROC, the results indicated that PAPP-A had a significant relationship with the incidence of preeclampsia, preterm birth, and fetal low birth weight (p < 0.001). However, β-hCG levels showed no significant relationship with adverse pregnancy outcomes. Conclusions: The result of this study revealed that lower level of PAPP-A and β-hCG could be a predictive factor in preterm labor. Also, this study indicated that PAPP-A measurements could be a screening test for adverse pregnancy outcomes, such as preeclampsia, low birth weight and preterm labor.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Divisions: | University Portal > Hospitals > hoskosar University Portal > research center > kcrdu |
| Depositing User: | pr kcrdu portal |
| Date Deposited: | 21 Sep 2022 05:01 |
| Last Modified: | 21 Sep 2022 05:01 |
| URI: | http://eprints.qums.ac.ir/id/eprint/9077 |
Actions (login required)
 |
View Item |
